Abstract
Summary
Perphenazine and reserpine have significant antiemetic activity against staphylococcal enterotoxin induced emesis in monkeys; chlorpromazine and cyclizine lactate have little or no protective activity. Perphenazine gave the best protection and was effective at 50 μg/kg, intravenously; it inhibited vomiting even when administered 45 min after the enterotoxin had been fed. Pretreatment of monkeys was necessary for protection with reserpine. The effective drug levels did not greatly depress the medullary vomiting center. Perphenazine had some protective effect in dogs being challenged with intravenous injection of enterotoxin.
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