Abstract
Summary
Homogenates of kidney, liver and spleen tissue from normal and anemic dogs were assayed for erythropoietic activity by their effect on Fe59 red cell incorporation in starved rats. A slightly higher incorporation resulted from administration of an extract of anemic kidney than from extract of normal kidney or anemic liver or anemic spleen. This difference was sufficient to suggest the importance of developing methods for concentrating and purifying the erythropoietic activity of tissue homogenates to help clarify the role of kidney in production of erythropoietin. Methods for fractionation and concentration are being investigated.
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