Abstract
Summary
Experimental wound infections with small inocula of staphylococci were regularly produced in rabbits. Prophylactic penicillin was effective in preventing such experimental wound infections due to “penicillin-resistant” staphylococci when size of inoculum was small and when the infecting organisms were derived from environment containing no penicillin. Under similar conditions penicillin was not effective in preventing wound infection due to small inocula of “penicillin-resistant” staphylococci which were derived from an environment containing penicillin.
The authors acknowledge technical assistance of Charmion Carnes.
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