Abstract
Conclusion
6-methyl-prednisolone is absorbed rapidly and in substantial amounts from the rectum in normal individuals and in patients with ulcerative colitis. Half of the 6-methyl-prednisolone absorbed from the rectum and excreted in the urine is eliminated within 6 hours. The beneficial action of 6-methyl-prednisolone retention enemas may be systemic as well as local.
The authors express their gratitude to Doctors Attallah Kappas and George V. LeRoy and to Lee Wilcoff for aid in this study.
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