Abstract
Summary
The equimolecular complex of 4,4'dinitrocarbanilide and 2-hydroxy-4,6-dimethylpyrimidine (Nicarbazin, Merck), when fed at 0.04% of a low-fat, low-cholesterol diet to 6-8 month-old laying hens, doubled plasma cholesterol within 2 weeks and tripled it within 4 weeks. Thereafter the hypercholesterolemia was maintained at levels between 600 and 900 mg % for as long as 32 weeks. The hypercholesterolemia appears to be induced and sustained by continuous resorption of yolk from partially developed ova, while yolk material continues to be deposited in other ova just beginning the growth cycle.
Technical assistance of Kurt Textor and Eugene Borbely is gratefully acknowledged. Nicarbazin was supplied as 25% premix through courtesy of Dr. A. Zeissig, Merck Sharp & Dohme.
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