Abstract
Summary
1. Among weanling rats receiving 0.3% dietary BAPN fumarate those showing less severe skeletal deformities tended to excrete relatively larger amounts of cyano-acetic acid (CAA) in urine, and vice versa. Increasing dietary casein level from 12 to 24% resulted in less severe skeletal lesions and higher urinary CAA excretion for a given dosage of BAPN. 2. Appreciable urinary excretion of CAA followed injection of the following organic nitriles into rats: 2,2′-iminodipropionitrile (IDPN), ethylene cyanohydrin, succinonitrile, 5-aminovaleronitrile, and n-valeronitrile. Traces of CAA resulted from injection of n-hexanenitrile and 4-aminobutyronitrile.
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