Abstract
Summary
1. A comparative study has been carried out to determine the effect of LSD and bufotenine on climbing time of trained rats. 2. Both drugs produced similar effects in these animals. However, LSD was effective at smaller doses but had a shorter duration of action than bufotenine. 3. Tolerance to repeated LSD injections was found and a similar tolerance to bufotenine was demonstrated. 4. Prolongation of climbing produced by submaximal doses of both LSD and bufotenine was potentiated when brain serotonin levels were altered by pretreatment of animals with reserpine, 5-HTP or iproniazid. Highly effective doses of LSD and bufotenine were inhibited by 5-HTP pretreatment, 5. Based on evaluation of climbing time delay produced in trained rats the psychogenic activity of LSD and bufotenine appears to depend on a similar mechanism of action.
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