Abstract
Summary
A light-dark synchronized activity rhythm persists in pituitary-isografted C mice. The adrenal cycle probably persists in mice with a significantly altered estrous cycle (1,2). Multiple pituitary isografts are associated with adenocarcinomata and adenoacanthomata in virgin female mice of the D8 and C stocks. The carcinogenic effect of the pituitary isografts is statistically significant and not a result of trauma. Number of implants as well as presence or absence of mammary tumor agent also are significant variables, but neither variable is critical to carcinogenesis from pituitary isografts, under the conditions studied. Insertion of the hypothalamus at the time of pituitary implantation delays mammary carcinogenesis by mechanisms as yet unknown.
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