Absence of Hypoglycemia and Hypophosphatemia Following Initial Dosages of Phenethylbiguanide (D.B.I.) ∗ †

Abstract

Summary and Conclusion

1. Phenethylbiguanide (D.B.I.) in a single dose of 150 mg failed to induce a decrease in blood sugar or in serum inorganic phosphorus during succeeding 5 hour period in diabetic patients previously controlled with or without insulin. 2. This amount did not affect blood sugar and serum inorganic phosphorus changes during glucose tolerance tests and insulin tolerance tests in the same subjects. 3. Since these amounts of D.B.I, when continued on daily dosage do induce hypoglycemia, it is evident that such responses result either from accumulation of the drug in body fluids and tissues, represent acquired responsiveness upon continued exposure, or both.