Abstract
Summary
Glucocorticoid properties of subcutaneously and orally administered triamcinolone acetonide were assayed in immature adrenalectomized rats by liver glycogen deposition and thymus involution. Subcutaneously, triamcinolone acetonide is about 3 times as potent as triamcinolone on liver glycogen assay and 7 times triamcinolone on the thymolytic assay. Oral activities of triamcinolone acetonide also were greater than those of the parent steroid. Triamcinolone acetonide was capable of inducing a diuretic, natriuretic and kaliuretic response in adrenalectomized rats. Triamcinolone acetonide was more active than either desoxycorticosterone or triamcinolone for maintaining the life of immature, adrenalectomized male rats.
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