Abstract
Summary
Four polar, water-soluble metabolites of chlorpromazine were separated from urine by use of a cation exchange resin. These were shown to be glucuronides by release of free glucuronic acid and less polar, ether-extractable phenothiazines as a result of β-glucuronidase hydrolysis. Presence of enolic functions in these released phenothiazines was shown by their extractability from an acidic medium. Results strongly suggest hydroxylation of chlorpromazine and subsequent conjugation with glucuronic acid as an important route of chlorpromazine metabolism and detoxification in man.
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