Abstract
Summary
The effects of δl-testololactone, δ4-androstene 17α-ol-3-one-17-β-oic acid, and fluoromevalonic acid upon in vitro conversion of labeled acetate and labeled mevalonate into cholesterol were studied. All of these compounds inhibited conversion of acetate, while only the latter 2 inhibited conversion of mevalonate. Fluoromevalonic acid was the most potent inhibitor studied. Fluoroacetate, fluoride ions, and zinc ions had no effect on the mevalonate system. Of these substances only zinc ions inhibited conversion of acetate to cholesterol.
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