Abstract
Summary
1. DPN injection produces toxic effects in mice similar to those described for nicotinamide analogs. 2. Toxicity of injected DPN is influenced by environmental temperatures; both cold and hot environment enhances toxicity. 3. Simultaneous cortisone potentiates the effect of heat and cold. 4. These effects are discussed as they bear on inhibition of DPN-ase activity of reserpine, promazine and nicotinamide.
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