Abstract
Summary
Feeding various bile acids to mice for 3 weeks had the following effects: 1. Cholic acid increased hepatic and intestinal cholesterol levels, but had no effect on kidney cholesterol. It decreased hepatic cholesterol synthesis rates, but had no effect on intestinal synthesis rates. 2. Hyodeoxycholic and lithocholic acids decreased liver cholesterol levels. Hyodeoxycholic acid had no effect on intestine and kidney cholesterol, or on intestinal cholesterol-x-C14. Both acids effected large increases in hepatic cholesterol synthesis. 3. Deoxycholic acid significantly decreased liver, small intestine and kidney cholesterol levels. It also decreased hepatic cholesterol synthesis. 4. Results of this study suggest that homeostatic control of cholesterol metabolism in tissues other than liver is independent of hepatic control.
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