Abstract
Summary
Dietary administration to rats of the anti-thyroid drug, propylthiouracil, prevented development of hypertension accompanying administration of hypertonic (1.75%) NaCl solution as sole drinking fluid. Propylthiouracil administration prevented not only the expected rise in systolic blood pressure but also cardiac and renal hypertrophy. Although the results suggest the possibility that thyroid gland may play a role in salt hypertension, they could be accounted for by extra-thyroidal effects of the drug.
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