Abstract
Summary
Sporadic polyarthritis in rats observed during spontaneous and induced regression of a lymphosarcoma has been investigated. Cultural studies of the involved periarticular tissues and the tumor yielded PPLO, Mycoplasma arthritidis. The respective roles of PPLO, tumor-necrotizing bacterial polysaccharide, and tumor regression in production of the polyarthritic lesions have been evaluated. Arthritis occurred only in PPLO-infected rats with concurrent or prior necrosis of tumor tissue. Bacterial polysaccharide and viable tumor were not essential.
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