Comparative Toxicity of 3-Nitro 4 Hydroxyphenylarsonic Acid and Its Formaldehyde Dimer to Chicks

Abstract

Summary

The formaldehyde dimer of 3-nitro 4 hydroxyphenylarsonic acid was slightly less growth stimulatory than 3-nitro when fed to chicks at a level equivalent to 49.5 mg of 3-nitro/kg diet. Both arsenicals stimulated growth when fed at a level equivalent to 74.25 mg of 3-nitro/kg diet, with the dimer somewhat more effective. There was little difference between the 2 when fed at a level equivalent to 198 mg 3-nitro/kg diet. Liver arsenic stores were greater in chicks fed the dimer at each of the 3 levels of comparison. Administered as a single oral dose at levels approximating 100 and 200 mg/kg body weight, survival out of 10 chicks treated was 7 and 1 respectively, for 3-nitro and 8 and 0 for the dimer.