Abstract
Summary
1. Rabbits exposed to staphylococcal toxoid early in life have a reduced capacity to respond to the same toxoid in later life as evidenced by development of low anti-hemolysin titers. 2. Resistance to dermonecrotic effects of staphylococcal toxin is also reduced by early exposure of rabbits to the toxoid. 3. The Arthus response does not play a role in development of lesions under conditions of these experiments. 4. The possible role of acquired tolerance and similar phenomena in infectious diseases is also discussed.
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