Abstract
Summary
1. Conjugation and rate of removal of sulfobromophthalein from the blood stream were studied in hepatectomized and hepatectomized-nephrectomized dogs. 2. Clearance of BSP from blood of hepatectomized dogs occurred at a slow but significant rate. Only 10% of cleared dye was excreted in urine. Conjugates of BSP appeared in serum and in greater percentage in urine. 3. Hepatectomized dogs after nephrectomy still cleared BSP at significant rate but had only questionable traces of metabolites in the serum. 4. It was concluded that the kidney is capable of conjugating BSP but that most of the dye clearance in the hepatectomized dog can be attributed to extrarenal mechanisms in the peripheral tissues.
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