Studies of Properdin System in Human Cancer Cell Cultures. ∗

Abstract

Conclusions

1) Neither properdin (up to 20 U/ml) nor absence of detectable properdin (<1/2 U/ml) had any apparent influence upon growth rate or morphology of human cancer cells HEp #2 or J-111 in tissue culture, nor upon their ability to propagate on subsequent homotransplantation. 2) Neither properdin nor complement was rapidly metabolized or inactivated by these cells in tissue culture. 3) Addition of properdin to tissue culture medium (in presence or absence of cells) caused a fall in C′1 titer and accelerated the fall of C′2 and C′4.