Abstract
Summary
Feeding of highly purified cholesterol to rabbits for 12 weeks resulted in high serum cholesterol and atherosclerotic lesions, which appear more severe than those obtained with commercial cholesterol. This latter contained about 2% impurities isolated from mother liquors after treatment of commercial cholesterol with anhydrous oxalic acid in organic solvents. Such impurities did not produce atherosclerotic lesions when fed to rabbits, but when given together with cholesterol caused less extensive lesions than those obtained with pure or commercial cholesterol.
The help of Erszebet Joachim, Eva Moring and Deirdre McLeod is gratefully acknowledged.
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