Abstract
Summary and Conclusions
Blood flow response to exercise was tested plethysmographically in 3 healthy subjects and 7 patients with non-gangrenous occlusive arterial disease of lower extremities, before and after intravenous administration of nylidrine hydrochloride, an adrenaline analog. Response in blood flow was significantly augmented after administratino of drug in all but one subject, who had severe bilateral frost bite. Since blood flow response to exercise takes place mostly in working skeletal muscles, it is concluded that the primary site of nylidrine action is in the vasculature of skeletal muscle. Nylidrine apparently enhances capacity of muscle vessels to respond to exercise.
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