Influence of N-Methylformamide on C 14 -Formate Incorporation III. Effect of Time of Administration of Isotope.

Abstract

Summary

1) The effect of NMF on rat liver metabolism has been shown to be qualitatively the same at 2 and 6 hour intervals after administration of the isotope as at 24 hours after administration. 2) The first peak of incorporation of formate into rat liver nucleic acids occurs 2 hours after administration, with a second peak 8 hours or after. Peak of incorporation into intestinal nucleic acids is around 4 hours after administration.