Abstract
Summary
A deficiency of biotin, superimposed over a simple PGA deficiency in rats resulted in further reductions in liver levels of PGA and CF, blood hemoglobin and, additionally, blood erythrocyte count. Administration of biotin to doubly-deficient animals caused almost complete restoration of liver levels of PGA and CF and of blood hemoglobin; under these conditions there was marked excretion of PGA in feces, but not in urine, the amount excreted exceeding by far the tissue rise in level of vitamin. It is suggested that biotin administration may influence synthesis of PGA by intestinal microflora and, as a consequence, improve tissue levels of the vitamin.
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