Protection Afforded Mice Against Tourniquet Trauma Induced Mortality By Ganglion Blocking Drug Chlorisondamine Dimethochloride

Abstract

Summary

Survival-mortality data were obtained for tourniquet traumatized, adult Carworth Farms male mice for 120 hours after zero hour (time of removal of both hind leg ligatures). Higher percent survivals were noted throughout for test mice injected intraperitoneally with chlorisondamine dimethochloride, 5 mg/kg, than for control traumatized mice injected with water. The p (probability) values for test vs. control mice were: (A) for mice injected at zero hour, 0.01 or less at 6, 24, 48 and 120 hours thereafter, and (B) for mice injected 15 minutes after zero hour, 0.01 or less ONLY at 6 hours thereafter.