Effect of Methylphenidate on Cardiovascular Actions of Pressor Amines

Abstract

Summary

Methylphenidate alters the pressor responses in the dog to a series of phenylalkylamines. The amines affected by this central nervous system stimulant are influenced in such a way as to fall into 3 distinct categories, i.e., 1) potentiated or not altered, 2) reversibly blocked and 3) irreversibly blocked. The differences in structure of pressor phenylalkylamines comprising the 3 groups are reviewed along with reference to other compounds which affect pressor action of these amines in a similar manner.