Absence of Gene Interaction in Mouse Hybrids,Revealed by Studies of Immunological Tolerance and Homotransplantation. ∗

Abstract

Summary and conclusions

1. C3H mice made tolerant by injection of A spleen cells at birth are tolerant of skin homografts from A strain and (A x C3H) F₁ donors. 2. C3H mice made tolerant by injection of (A x C3H) F₁ spleen cells at birth are tolerant of skin homotransplants from both A strain and (A x C3H) F₁ donors. These observations are interpreted as evidence indicating that new histocompatibility antigens do not derive from genie interaction during hybridization in the 2 inbred strains of mice in these studies.