Abstract
Summary
Fluorometholone is an unusual synthetic corticoid in the rat because its anti-inflammatory potency (131 X hydrocortisone) is much greater than its glucocorticoid potency (26 X hydrocortisone). Its potency in promoting development of ulcers of the pyloric portion of rat stomach is between its glucocorticoid potency and its anti-inflammatory potency. It does not cause sodium retention at doses in which a similar compound (differing only by presence of C-21 hydroxyl) does produce measurable sodium retention.
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