Abstract
Summary
Continuous phase contrast observation and microcinematographic recording of living rabbit kidney cell cultures infected with herpes simplex virus, established the following phenomena: 1. Progressive dissolution and dispersion of nucleoli, loss of nucleo-plasmic homogeneity, and appearance of intranuclear densification zone but not of a well delineated inclusion body. 2. Persistent activity of cytoplasmic organelles in cells with severe nuclear lesions. 3. Rapid (2-3 hours) formation of giant cells by cell confluence but not by cell division mechanism, accompanied by signs of cytoplasmic liquefaction. The significance of these data is discussed.
Get full access to this article
View all access options for this article.