Abstract
Summary
1. A single subcutaneous injection of 2.14 mg of 4′-fluoro-10-methyl-1,2-benzanthracene in albino rats produced a severe and fatal periarteritis in 4 to 8 weeks. Similar lesions were seen after injection of one-half as much of this hydrocarbon, but they developed more slowly. Equivalent levels of 10-methyl-1,2-benzanthracene or the solvent alone were ineffective. 2. The most severe lesions were observed in pulmonary arteries; this finding is in accord with the cyanotic conditions of some rats. Hyaline necrotic lesions were observed in renal arterioles and glomerular capillaries. 3. A possible immunological basis for these lesions is discussed.
Get full access to this article
View all access options for this article.