Abstract
Summary
Several preparations of highly purified α-MSH were studied for their adrenocorticotropic activity in vivo and in vitro using USP Reference Corticotropin as a Standard. They showed corticotrophic activity by either assay procedure. β-MSH did not demonstrate similar activity. In view of data obtained, it is suggested that the “active core” of ACTH molecule may be no longer than the tridecapeptide from the N-terminus.
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