Abstract
Summary
The analgesics codeine, morphine, and l-14-hydroxydihydromorphinone (Numorphan) produced inhibition of the conditioned avoidance-escape response in rats, a widely used tranquilizer test. The potencies in blocking conditioned response correlated roughly with analgesic potencies. The very potent analgesic, l-14-hydroxydihydromorphinone, exhibited by subcutaneous injection slightly more conditioned response blocking activity than perphenazine, one of the most active tranquilizers now in clinical use.
Get full access to this article
View all access options for this article.