Abstract
Summary
Acetylene dicarboxylate (ADC) is a competitive inhibitor of succinoxidase. The apparent dissociation constant of the ADC-enzyme complex is about 1/5 that of the succinate-enzyme complex when the inhibitor is added to the enzyme after or along with the substrate. However, when the enzyme, inhibitor, and substrate are incubated 18 hours before assay, the value of KI is about 1/25 that of KS.
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