Abstract
Summary
1) Rapid intravenous injection in monkeys of adequate doses of Mikedimide (3, 3, methylethyl glutarimide) induced clinical convulsions which were readily controlled by intravenous barbiturates. 2) Thresholds for clinical convulsions were lower in epileptic than in normal monkeys. 3) A challenge dose (4 mg/kg) is suggested as one capable of producing clinical seizures in epileptic but not in non-epileptic monkeys.
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