Abstract
Summary
1. Decreased lipoprotein lipase response in obstructive jaundice in man has been confirmed by complete ligation of the common bile duct in dogs. 2. Subsequent increased lipoprotein lipase response in these dogs after chronic complete cholestasis of 4 to 10 weeks is attributed to development of biliary cirrhosis. 3. While lipoprotein lipase response was generally inversely proportional to total serum lipids, cholesterol, and lipid phosphorus levels, this relationship was by no means absolute. 4. Possible pathogenetic mechanisms for decreased lipoprotein lipase response in obstructive jaundice have been discussed. These mechanisms are being investigated.
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