Abstract
Summary
A feedback mechanism, whereby conjugated bile acids control oxidation of cholesterol in liver, has been discerned in vitro. Addition of cholic acid conjugates depressed oxidation of cholesterol, but not that of sodium pyruvate or 3a, 7a, 12a-trihydroco-prostane, by fortified rat liver mitochondrial preparations. Preparations from livers of rats, deprived of bile salts by interruption of enterohepatic circulation, oxidized cholesterol to a greater extent than controls. The site of action of the feedback effect is discussed briefly.
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