Abstract
Summary
A method for measuring activity of monoamine oxidase inhibitors as a function of suppression of 5-hydroxy-indoleacetic acid (5-HIAA) excretion is described. Increased excretion of 5-HIAA after 5-hydroxy-tyramine (5-HT) is effectively blocked by orally administered iproniazid, JB-516, and several harmala alkaloids. Correlation of these results with increased brain 5-HT is presented. Instances of non-correlation such as lack of effect of oral harmine on brain 5-HT with concomitant suppression of 5-HIAA excretion are discussed.
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