Abstract
Summary
Serum hemolysin titers were correlated with weight of remnant spleen present in groups of partially splenectomized NIH mice sacrificed 5 days after intravenous immunization with sheep erythrocytes. Total splenectomy of mice completely suppressed hemolysin formation after intravenous immunization and was associated with a 27% decrease in amount of antibody formed, and a 24 hour delay required for development of peak serum titer. Complete suppression of antibody formation was partially reversed by autologous spleen transplants in splenectomized mice of 2 strains; by isologous transplants in Balb/c but not in NIH mice; and unaffected by homologous transplants in either of the 2 strains.
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