Antibody Response of Adult Mice to Virus of Foot-and-Mouth Disease

Abstract

Summary

Normal adult female mice were inoculated with the virus of foot-and-mouth disease, and serums obtained from these animals at intervals up to 3 months after inoculation were tested for their neutralizing capacities. Neutralizing antibody was detected as early as 3 days after inoculation and increased gradually until a maximum was reached at 20–30 days. The antibody persisted at a high level throughout remainder of 84-day period.