Abstract
Summary
1) A procedure has been developed for extracting and refining tumor factor contained in mouse leukemic tissue. The refined preparation repeatedly induced a variety of neoplasms in high percentage of inoculated animals, but no leukemia was induced. 2) Results were reproducible and time of tumor appearance predictable. Tumors developed at earlier age than when crude cell-free filtrates are used. 3) This work suggests that an attempt be made to isolate tumor factor from Drosophila, fish lymphoma, chicken lymphoma, Lucké frog kidney tumor, etc., so that a tumor-inducing mechanism common to Metazoan life may be demonstrable. 4) By purification technic discussed, tumor factor has been isolated from Hodgkin's disease tissue and other neoplastic tissues from human beings to be reported.
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