Effect of Plasma from Wounded Donors on Nitrogen and Sulfur Excretion. ∗

Abstract

Summary

Rats, on a protein deficient diet, were given reconstituted plasma from wounded donors. These animals excreted less nitrogen and sulfur than did comparable rats given plasma from normal donors. Similar results were obtained on excretion of S³⁵, administered as labeled cystine. After 10 days, liver and kidney of rats receiving normal plasma were significantly heavier than in rats getting plasma from wounded animals. The data appear to indicate that plasma from wounded rats contains a factor(s) which affects metabolism of nitrogen and sulfur.