Abstract
Conclusions
Rabbit antiserum to a saline soluble component of human brain, when mixed with spinal fluids and with sera from patients with various illnesses, gave a precipitate with all spinal fluids and with 17 out of 244 human sera. These positively reacting sera were from 4 schizophrenic and 13 paretic patients. On the other hand, human brain antigen mixed with human serum gave a precipitate in 5 out of 244 cases. The 5 sera were from one arthritic, one paretic, one chronic schizophrenic and 2 alcoholic patients. The few sera reacting positively show that this is not a general flocculation phenomenon, but whether immune systems actually related to brain are being tested here, is the subject of further study. The relatively high number of paretic patients giving a positive reaction with antibrain serum may have a bearing upon this. These results may provide a lead for further investigation of brain disease.
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