Abstract
Summary
When glycogen is incubated with normal rabbit blood, both serotonin and histamine are released from the platelets. EDTA inhibits this release. Intravenous injection of glycogen into rabbits produces a marked fall in whole blood concentration and a rise in lung content of serotonin and histamine. These results are secondary to trapping of platelets in the lung. In addition, both serotonin and histamine are released into the plasma. All of these changes are identical to those obtained when antigen is injected intravenously into a sensitized rabbit or when an antigen-antibody complex precipitate is injected intravenously into a normal rabbit.
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