Abstract
Summary
A 10% solution of acetylcholine chloride injected into the globus pallidus of persons with Parkinsonism resulted in initial excitatory stage with increase in tremor and parasympathetic activation. Parasympathetic response was blocked by intracerebral injection of an anticholinergic drug, oxyphenonium bromide. The exact mechanism of drug action is not known, although cholinergic sensitive regions appear to exist in or near the globus pallidus.
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