Abstract
Summary
1) The effect of method of preparation of the extract, sonic disintegration, grinding with alumina, disruption in ball mill, or sudden release of pressure in the French Cell, on P/O ratio of crude extracts of A. agilis with succinate as substrate has been investigated. 2) The P/O ratios show a wide range of variation with different extracts prepared by same method, but with all methods used, P/O ratios were low compared to mycobacterial and mammalian systems. Some evidence is presented that a labile factor is present in extracts and is responsible, at least in part, for the low ratios observed.
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