Fate of Radiosulfate in Multiple Myeloma. ∗

Abstract

Summary

Radiosulfur (S³⁵) as sodium sulfate was administered intravenously in doses ranging from 0.867 to 2.07 mc, to 9 patients with multiple myeloma and to 10 patients with other neoplasms. The fate of administered sulfate was apparently the same for both groups of patients. S³⁵ was rapidly turned over and excreted; 30 to 90% appeared in urine within 48 hours. Blood levels of S³⁵ closely paralleled those of plasma and decreased rapidly. It was possible to demonstrate that 3 exponential rates governed the disappearance of S³⁵ from whole blood and plasma. The mean zero-time radiosulfate space of dilution was 9.29 ± 2.16 liters for patients with multiple myeloma and 11.4 ± 2.87 liters for those with other neoplasms. By technics employed, a preferential retention of sulfate could not be demonstrated in multiple myeloma as compared to other neoplasms.