Abstract
Summary
Studies of incorporation of C14-labeled acetate into MPS, hyaluronic acid and chondroitin sulfate from skin and chondroitin sulfate from cartilage of rabbits with and without serum sickness, indicated little difference effected by serum sickness. Specific activities of skin MPS were possibly increased. Greater incorporation of the isotope was observed in liver and muscle glycogen from rabbits with serum sickness. Further study of other hypersensitivity reactions and of tissues more specifically involved by such reactions need investigation. Such experiments, currently in progress utilizing the local Shwartzman lesion, do indicate a considerable increase of metabolic activity of the MPS.
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