Abstract
Summary
1. X-radiation administered prior to Coxsackie virus inoculation increased and prolonged the yield of virus from selected tissues, particularly the pancreas. 2. X-radiation administered prior to virus inoculation inhibited the specific immune response. 3. The deleterious effects of irradiation on antibody formation were not long lasting, in that virus reinoculated 30 days after x-ray exposure evoked a prompt secondary response equal to that of control mice. 4. X-radiation exposure prior to a second inoculation of virus inhibited the secondary response in both the previously irradiated and control mice. 5. These data are compatible with the hypothesis that increased viral proliferation in x-radiated animals is due to the inhibition of the antibody response.
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