Abstract
Summary
1) ECHO-12 prototype virus, 2-85-4 Travis, was isolated from rectal swab of a normal American child in the Philippines, collected in 1953. A rise in NA was demonstrated in serial serum specimens. This virus was antigenically distinct from all other currently recognized enteroviruses which are cytopathogenic for rhesus MKCC, as determined by reciprocal NA tests with all these viruses and their respective monkey or rabbit antisera. 2) Specificity and biologic properties of ECHO-12 virus in certain laboratory animals, chick embryos, and cell cultures are described. The ability of ECHO-12 virus to form plaques in both rhesus and patas MKCC and to hemagglutinate human type O erythrocytes at 4, 25 and 37°C further distinguishes this virus from the first 19 of the 24 recognized ECHO types. Prototype ECHO-12 infected rhesus MKCC fluids can be used in CF, NA and HAI tests. 3) This virus has now been repeatedly isolated from individuals in the Philippines, from United States and Mexico. Antibodies are present in Japanese gamma globulin. One isolation of virus was made from a throat swab.
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