Abstract
Summary
1. A specific sensitive method for detection in biological materials of 4M20 has been presented. 2. Plasma levels, urinary and fecal excretion of 4M20 in the dog after intravenous and oral administration were studied. These studies indicate almost complete destruction of the material after administration by both routes. Less than 0.5% of unchanged material was recovered in urine after intravenous administration and only traces were found in feces. After oral administration only traces of unchanged material were found in urine and feces. 3. The major metabolite of the drug was isolated by means of chromatography. It has been partially characterized as oxidation product with hydroxylation occurring at position 2. Other undetermined changes also occur in the molecule.
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